RNA Details
Disease Name
heart failure
Tissue
heart
RNA Symbol
Snhg20
RNA ID
RNA Type
lncrna
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Cell Counting Kit-8 assays;dual-luciferase reporter assay etc.
Target
miR-335
Pathway
NA
PubMed ID
Title
Inhibition of Long Noncoding RNA SNHG20 Improves Angiotensin II-Induced Cardiac Fibrosis and Hypertrophy by Regulating the MicroRNA 335/ Galectin-3 Axis
Year
2021
Function
"Downregulation of SNHG20 effectively enhanced cell viability and decreased cell size of HL-1 cells and the expression levels of fibrosis-related proteins (fibronectin, collagen IaI, and alpha-SMA) and apoptosis-related proteins (cleaved caspase-3 and cleaved PARP), which were induced by angiotensin II treatment."